The maximum clique problem in a weighted graph in general is intractable. In your case, if the graph contains N nodes, you can enumerate through all possible k-cliques in N ** k time. If k is fixed (don't know if it is), your problem is trivially polynomially solvable, as this is a polynomial in N. I don't believe the problem to be tractable if k is a free parameter because I can't see how the assumption of a k-partite graph would make the problem significantly simpler from the general one.
How hard your problem is in practice depends also on how the weights are distributed. If all the weights are very near to each others, i.e. the difference between "best" and "good" is relatively small, the problem is very hard. If you have wildly different weights on the edges, the problem can be easier, because a greedy algorithm can give you a good "initial" solution, and you can use that and subsequent good solutions to limit your combinatorial search using the well-known branch-and-bound method.