Different styles for Windows forms in Ironpython
No correct solution
As an interface designer, it's important to use an many standard windows controls as possible. The more your app looks like the microsoft ones users are used to, they will become more comfortable with it quicker.
A good example is how out of place iTunes and Safari look in windows. My tip is to just keep it with the windows look.
See Graphics and Drawing in Windows Forms, or Custom Control Painting and Rendering.
WinForms provides hooks to change the look of its controls, or you can create your own.
If possible, look into changing your app to
WPF, where the separation of style and behavior is a central part of the design.
A simple example, WPF GUI using XamlReader, shows how IronPython might use