CLS compliance is a property of code, not of a language. There was an early version of VB.NET where you couldn't write non-compliant code by accident. That didn't last long, it acquired support for unsigned integral types somewhere around 2005.
It is still relevant, you still can write a library that might be used in a language that was ported to .NET and doesn't support unsigned integers or is case-insensitive, etcetera. The approach is simple, you just avoid using non-compliant features in your code and your assembly should work just fine. Which is very easy to do, add this line of code to anywhere:
[assembly:CLSCompliant(true)]
And the compiler will give you a warning when you broke the rules.