The AppDelegate class cannot be used as a view controller, if that's what you're asking. Your AppDelegate class should be creating an instance of your main View Controller, which loads your main .xib file. Unless you're referring to defining the main Xib in your target configurations, but that's pretty old school.
Are you constrained by the version of iOS you need to support? Because you could avoid using .xib files altogether by using storyboards if you can use iOS 5.0 and up.