You need to use nested Group
in your layout. Some thing like this:
<?xml version="1.0" encoding="utf-8"?>
<s:View xmlns:fx="http://ns.adobe.com/mxml/2009"
xmlns:s="library://ns.adobe.com/flex/spark" title="HomeView">
<s:layout>
<s:VerticalLayout gap="5" horizontalAlign="left" paddingLeft="5" paddingRight="5" paddingTop="5" paddingBottom="5"/>
</s:layout>
<s:Group width="100%">
<s:Button id="button1" right="0"/>
<s:Button id="button2" left="0"/>
</s:Group>
</s:View>