It's a little bit difficult to understand the question completely. If you're trying to output a class when the page loads, that's very easy using php:
<?php
$classVariable = "myClass";
?>
<div id="someID" class="<?php echo $classVariable; ?>">Some content</div>
PHP loads once, before anything else on the page, and never runs again. You can call other scripts using AJAX which can then return data that you can use. For example (using jquery)
<script type="text/javascript">
$.get("path-to-myscript.php", function(response){
// read the response in, perhaps you grab some class name from it
// for demo purposes, lets say this response is in json formatted as a simple string:
// '{ "class" : "someClass" }'
var data = $.parseJSON(response);
var newClass = data.class;
$("#someID").attr("class", newClass);
});
</script>