The quickest solution will be to use a python module called binascii that has a selection of functions for converting the binary string to an ascii string: http://docs.python.org/2/library/binascii.html
EDIT: The b means that it is a byte array and not a literal string. The correct way to convert the byte array to a litteral string will be to use the str() function:
str(b'1234, asdf, 456, jkl', 'ascii').split(",")
this gives the output you want: ['1234', 'asdf', '456', jkl']
I hope that helps!