pep381 client use http, but pypi can only be used https. This program is not implemented function that redirect url. I modified the program as this.
file: (YOUR INSALLED DIRECTORY)/pep381client/__init__.py
9: -BASE = 'http://'+pypi
+BASE = 'https://'+pypi
28: - _conn = httplib.HTTPConnection(pypi)
+ _conn = httplib.HTTPSConnection(pypi)
37: - _conn = httplib.HTTPConnection(pypi)
+ _conn = httplib.HTTPSConnection(pypi)