First option you can do this way-
$M = 'M';
$age = 15;
$query = $this->createQueryBuilder('t')
->where('u.gender = :M AND u.age = :age')
->setParameters(array('M'=> $M,'age'=>$age);
another way to do this-
$query = $this->createQueryBuilder("t")
->where("u.gender = 'M' AND u.age = 15");