If all you do is print the prize:
In [77]: print "{:,.2f}£".format(random.randrange(100000))
26,467.00£
Or if you want the currency symbol in the front
In [78]: print "£{:,.2f}".format(random.randrange(100000))
£80,244.00
If you already have the prize
variable:
In [80]: print "£{:,.2f}".format(prize)
£64,058.00