Every time you compile your Android project (if you are working on eclipse at least) the R package gets deleted and then gets rebuild. This error is pretty common and it means that you have an error in your code that stopped the building process and so also the creation of the R package.
If it worked before then try identifying at which time did it stop working and analyze the code that caused it not to compile so to find the error. Normally the error is in the XML layout file that prevented the application from being built
It may be that your problem is caused by a different reason, but in every case that that I've seen that this problem is present, the cause is always a compilation error.
Happy hunting :)
edit: Check out this answer, it may contain just the info you need