Design Patterns for Coordinating Change Event Listeners

Question

I've been working with the Observer pattern in JavaScript using various popular libraries for a number of years (YUI & jQuery). It's often that I need to observe a set of property value changes (e.g. respond only when 2 or more specific values change). Is there a elegant way to 'subscribe' the handler so that it is only called one time? Is there something I'm missing or doing wrong in my design?