Use re.split.
With a sample of your data's format, it may be possible to do better than this, but without context we can still show how to use this with the code you have provided.
To use re.split():
import re
with open('filename', 'r') as f:
list1 = [re.split('[(#]+', line.strip())[0].split() for line in f]
Notice that the first parameter in re.split() is a regular expression to split on, and the second parameter is the string to apply this operation to.
General idea from: Splitting a string with multiple delimiters in Python