Thanks all for your providing help.
We solved this issue while analyzing root cause.
Sitecore was running agents after certain time interval and it was failing to complete it because on dependency on another thing. So at last all thing mess with creating a dead end loop. Which was eating all CPU memories. So it was not communicating well with database servers to get data.
After resetting IIS, all jobs are ended for a while and it works after same dead loop.