The key is to be mindful of the time window you are viewing. Towards the upper right corner is the picker for date and time window selected. As long as you didn't change it, typically it persists from view to view but it's still good to double-check.
Also, the information isn't presented the same.
For example, on the Application > (Application Name) > Monitoring > Overview there is a chart showing response times over the time window selected and the chart has a value posted above it that is an average for the time window. Also, each component of the chart (database, web external and JVM) are also averages. You can hover with a cursor over any time point in the chart to see the data for that moment.
As to the Transactions, how it appears depends greatly on the selections from the dropdown selectors. For example, the Transactions list could be the most consuming or the slowest response transactions. This information could differ greatly from the average, especially if there are a sufficient number of fast transactions.
Let us know if this information is helpful. If you need further clarification, I recommend creating a ticket through http://support.newrelic.com so we may look at the data more specifically.