Something like this seems to work on trivial data:
>>> regex = re.compile(r'^(.*(?<=\D)\d{4}(?=\D))(.*)')
>>> strings = ['foo', 'bar', 'baz', 'foo 1999', 'foo 1999 never see this', 'bar 2010 n 2015', 'bar 20156 see this']
>>> [regex.sub(r'\1', s) for s in strings]
['foo', 'bar', 'baz', 'foo 1999', 'foo 1999', 'bar 2010', 'bar 20156 see this']