Here, I have GNAT GPL 2012 installed in /opt/gnat-gpl-2012
and I just say in a Terminal window
/opt/gnat-gpl-2012/bin/gps &
Up to Lion, X11 came with the OS (I think it may have been an optional install). In Mountain Lion, Apple no longer provide an official X11; however, when I started GPS for the first time on this new machine - as above - I was told how to install XQuartz. It Just Worked.