I used to use Komodo edit, but not anymore as It's more of a text editor than an IDE. I reccomend using Ninja-IDE or Eclipse with PyDev. But if you insist on using Konodo Edit, here's an option: Go here: Toolbox > Add > New Command... in the top field enter the name 'Run Python file' or something else. Then go to the 'command' field and enter this:
%(python) "%F"
Optionally, you could also specify key binding for fast python executing.