#r::
Run C:\Users\Hassan\Desktop\runescape.exe
Run C:\Program Files (x86)\Mumble\mumble.exe
Run C:\Users\Hassan\AppData\Roaming\Spotify\spotify.exe
Run http://www.google.com
Run http://www.zybez.com
Run http://www.reddit.com
return
Don't put stuff on the same line as the hotkey. You might also need to add http:// to the urls.