If you don't mind comparing indexes or column names, you can convert your DataFrame to tuple:
>>> df1 = pd.DataFrame({1: [1,2,3]})
>>> df2 = pd.DataFrame({1: [1,2,3]})
>>> hash(tuple(tuple(x) for x in df1.values)) == hash(tuple(tuple(x) for x in df2.values))
True
>>> id(df1) == id(df2)
False
You can also use map function instead of generator:
tuple(map(tuple, df1.values))
If you need to compare indexes too, you can add it as a column. You can also keep column names by creating namedtuple:
>>> from collections import namedtuple
>>> from pprint import pprint
>>> df = pd.DataFrame({1: [1,2,3], 2:[3,4,5]})
>>> df['index'] = df.index
>>> df
1 2 index
0 1 3 0
1 2 4 1
2 3 5 2
>>>
>>> dfr = namedtuple('row', map(lambda x: 'col_' + str(x), df.columns))
>>> res = tuple(map(lambda x: dfr(*x), df.values))
>>> pprint(res)
(row(col_1=1, col_2=3, col_index=0),
row(col_1=2, col_2=4, col_index=1),
row(col_1=3, col_2=5, col_index=2))
Hope it helps.