From the python 2 documentation (emphasis mine):
Plain integers: These represent numbers in the range -2147483648 through 2147483647. (The range may be larger on machines with a larger natural word size, but not smaller.) When the result of an operation would fall outside this range, the result is normally returned as a long integer (in some cases, the exception OverflowError is raised instead). For the purpose of shift and mask operations, integers are assumed to have a binary, 2’s complement notation using 32 or more bits, and hiding no bits from the user (i.e., all 4294967296 different bit patterns correspond to different values).
So yes: the integers are architecture specific for Python 2.
From the Python 3 documentation:
Plain integers: These represent numbers in an unlimited range, subject to available (virtual) memory only. For the purpose of shift and mask operations, a binary representation is assumed, and negative numbers are represented in a variant of 2’s complement which gives the illusion of an infinite string of sign bits extending to the left.
So no: the integers are not architecture specific for Python 3.