No you can't run the app without info.plist.
Every app and plug-in uses an Info.plist file to store configuration data in a place where the system can easily access it. OS X and iOS use Info.plist files to determine what icon to display for a bundle, what document types an app supports, and many other behaviors that have an impact outside the bundle itself. For better knowledge about this you can see this link:-
For more explanation you can see this post:-
https://stackoverflow.com/a/19833263/1865424
Hope this will help you out.