If you want to kill all the processes, may be, the fastest way is:
ALTER DATABASE [Data base name] SET SINGLE_USER WITH ROLLBACK IMMEDIATE
After that may be you want to go back to the previous database state:
ALTER DATABASE [Data base name] SET MULTI_USER
That is going to kill all the processes without restarting the server. If you want to kill a set of specific processes and "kill @spid" doesnt work I can only recomend you to use a DAC connection and see what happens.