Komodo (IDE or Edit) doesn't seems to have a very good Intellisense for Python so I ended up using PyCharm Community Edition and this IDE work like a charm.
It is easy to configure and the autocomplete always work and is fast to show (compared to Komodo's)
Komodo gives the possibility to change the behavior of the Ctrl+Space to use the Auto complete behavior but it still doesn't work the way I wanted because it doesn't always shows and when it does, it does it slowly
You can change your key bindings preferences with :
Edit > Preference > Editor > Key Bindings >
change the command "Editor : Trigger preceding AutoComplete list or CallTipe" key sequence to be "Ctrl + Space"
the Ctrl+Space is normally assigned to the "Code : Complete Word" command
But anyone who's using Python should definitly give a try to Pycharm.