You should never mix quoted and unquoted values in an IN list because the comparison rules for quoted values (such as strings) and unquoted values (such as numbers) differ. Mixing types may therefore lead to inconsistent results.
For example, do not write an IN expression like this:
SELECT val1 FROM tbl1 WHERE val1 IN (1,2,'a');
Instead, write it like this:
SELECT val1 FROM tbl1 WHERE val1 IN ('1','2','a');
Ref: http://dev.mysql.com/doc/refman/5.1/en/comparison-operators.html#function_in