For the completeness, and for people like me who stumbled upon this question because numpy's linear solver is not exact enough (it seems to be able to handle 64bit numbers, only), there is also sympy.
The API is somewhat similar to numpy, but needs a few tweaks every now and then.
In [104]: A = Matrix([
[17928014155669123106522437234449354737723367262236489360399559922258155650097260907649387867023242961198972825743674594974017771680414642705007756271459833, 13639120912900071306285490050678803027789658562874829601953000463099941578381997997439951418291413106684405816668933580642992992427754602071359317117391198, 2921704428390104906296926198429197524950528698980675801502622843572749765891484935643316840553487900050392953088680445022408396921815210925936936841894852],
[14748352608418286197003564525494635018601621545162877692512866070970871867506554630832144013042243382377181384934564249544095078709598306314885920519882886, 2008780320611667023380867301336185953729900109553256489538663036530355388609791926150229595099056264556936500639831205368501493630132784265435798020329993, 6522019637107271075642013448499575736343559556365957230686263307525076970365959710482607736811185215265865108154015798779344536283754814484220624537361159],
[ 5150176345214410132408539250659057272148578629292610140888144535962281110335200803482349370429701981480772441369390017612518504366585966665444365683628345, 1682449005116141683379601801172780644784704357790687066410713584101285844416803438769144460036425678359908733332182367776587521824356306545308780262109501, 16960598957857158004200152340723768697140517883876375860074812414430009210110270596775612236591317858945274366804448872120458103728483749408926203642159476]])
In [105]: B = Matrix([
.....: [13229751631544149067279482127723938103350882358472000559554652108051830355519740001369711685002280481793927699976894894174915494730969365689796995942384549941729746359],
.....: [ 6297029075285965452192058994038386805630769499325569222070251145048742874865001443012028449109256920653330699534131011838924934761256065730590598587324702855905568792],
.....: [ 2716399059127712137195258185543449422406957647413815998750448343033195453621025416723402896107144066438026581899370740803775830118300462801794954824323092548703851334]])
In [106]: A.solve(B)
Out[106]:
Matrix([
[358183301733],
[498758543457],
[ 1919512167]])
In [107]: