As an alternative to NuGet, you can use Bower for managing client libraries in your project and keep NuGet only for managing .NET libraries.
Sample video: http://blog.lambda3.com.br/2013/12/bower-e-npm-na-linha-de-comando-dentro-do-visual-studio-instalado-via-nuget/
Also take a look at this project template > ASP.NET Solution < on Visual Studio Gallery
It has a Node.js friendly directory layout and can be used as a starting point if you want to play with Grunt (or Gulp.js) and Bower automation tools.