Yes it can't, yet there is a work around, There are two options
Option 1: re-launch your app once the pdf thing is done after storing the values and current (at the time of exit) state of the app. You can use event listener or even a time stamp would do.
or
Option 2: on saving close the pdf activity or app
As per your question,
- User makes comments on the pdf
- User presses the save button
- changes(comments) are saved.
This is when you need to re launch your app or closing the pdf reader once the changes are saved, from the previous sequence.
Option 2 is much economical.
Hope this helps.