You could use something like the script below.
Please make sure to have a backup of your slides in case the script doesn't work as intended.
import os
import re
REGEX = re.compile("Slide([0-9]+).png")
for filename in os.listdir('.'):
match_ = re.match(REGEX, filename)
if match_:
slide_n = int(match_.group(1)) + 121
os.rename(filename, "Slide{}.png".format(slide_n))