yes. use the github-api package: https://www.npmjs.org/package/github-api
(from their docs)
Create Pull Request.
var pull = {
title: message,
body: "This pull request has been automatically generated by Prose.io.",
base: "gh-pages",
head: "michael" + ":" + "prose-patch",
};
repo.createPullRequest(pull, function(err, pullRequest) {});