If you happen to use g++/ld there are a few suggestions spelled out on How to remove unused C/C++ symbols with GCC and ld?
For example:
gcc -Os -fdata-sections -ffunction-sections test.cpp -o test.o -Wl,--gc-sections
-dead_strip
-dead_strip_dylibs
However I'm actually not sure it's possible for the compiler to do this in the general case. Consider a dependent shared library that has a weak reference to the library that you want to remove from your link line: How would the compiler know that it's safe to remove the library and/or symbols at that point?