This is a possibility:
# build small dataset
factor1 <- factor(rep(1:2,each=25))
factor2 <- factor(rep(3:4,each=25))
data<-rnorm(50,500,50)
alt.data<-rnorm(50,500,50)
frame <- data.frame(factor1,factor2,data,alt.data)
# subset the dataframe
subset(frame, data>500 & factor1==1 & factor2==3)
# summarize the one variable
summary(subset(frame, data>500 & factor1==1 & factor2==3)[,3])
# or if you want multiple columns
summary(subset(frame, data>500 & factor1==1 & factor2==3)[,3:4])
If I am interpreting your question correctly.