There are no problems running SystemC on a virtual machine. I do it regularly with VirtualBox. I run SystemC on Linux and Windows virtual machines, both 32-bit and 64-bit.
Unless there is a bug in the virtual machine software, a software application should behave identically when run on a physical or virtual machine.
Running multiple SystemC simulations concurrently on a virtual machine is also fine. The limit to how many simulations you can run concurrently, will be based on how much RAM you have available.