I figured it out.
select item, price1, price2, ((price2 - price1)/price1) * 100 as my_output from table
group by item, price1, price2
having ((price2 - price1)/price1) * 100 = (select( max(((price2 - price1)/price2) * 100)) from table)
It's messy, but does what I need it to.