It's Xamarin's decision to lock down Xamarin.iOS and Xamarin.Android projects to use .NET 4.5 profile by default, which enables huge benefits to be compatible with Microsoft. Unless Microsoft creates 4.6 or 5.0 profile, there is never a need for you to switch.
You can read from multiple locations the similar statements, such as "Now our class libraries are based on the .NET 4.5 profile",
http://docs.xamarin.com/releases/ios/xamarin.ios_6/xamarin.ios_6.3/
That's the obvious evidence.