Just for experiment, I've tried to upgrade PHP and MySQL to this version.
I've only get issue with ODBC connector:
ODBC error #01000: [unixODBC][Driver Manager]Can't open lib '/usr/lib64/libmyodbc5.so' : file not found
ODBC error #08S01: [unixODBC][MySQL][ODBC 5.3(w) Driver]Can't connect to local MySQL server through socket '/tmp/mysql.sock' (2)
At installing Plesk registers following DSN in /etc/odbcinst.ini
[MySQL]
Description = MySQL driver for Plesk
Driver = /usr/lib64/libmyodbc5.so
Setup =
FileUsage = 1
Driver64 = /usr/lib64/libmyodbc5.so
Setup64 =
UsageCount = 1
After installing MySQL 5.6 there is no more file /usr/lib64/libmyodbc5.so, because it's provided by mysql-connector-odbc-5.1.5r1144-7 which is not installed any more.
But there is /usr/lib64/libmyodbc5a.so and /usr/lib64/libmyodbc5w.so (from new 5.6 connectors).
I've replaced in /usr/lib64/libmyodbc5.so to /usr/lib64/libmyodbc5a.so in /etc/odbcinst.ini.
And as I can't get how to configure socket for this driver i've add symlink:
ln -s /var/lib/mysql/mysql.sock /tmp/mysql.sock
After that I've see that plesk mostly runs fine even with STRICT_TRANS_TABLES.
To keep link after server restart add following string in the beginning of /etc/init.d/mysqld:
if [ ! -L /tmp/mysql.sock ]; then ln -s /var/lib/mysql/mysql.sock /tmp/mysql.sock ; fi