Yes it is possible. Browser repl, noderepl, rhino repl...
Checkout the docs and read about piggieback. That's how it handles the envs
https://github.com/tpope/vim-fireplace/blob/master/doc/fireplace.txt https://github.com/cemerick/piggieback
Piggieback is included on Austin too so it should work if you :Connect to Austin and then :Piggieback with the environment you want
Edit: example
Read https://github.com/cemerick/austin/blob/master/README.md#usage and look at the environment that corresponds to how you started the repl. For example :Piggieback (cemerick.austin/repl-env)
. Look at the docs to see different repl-env that you can try.
Edit 2: Sample project Vim nRepl and node repl
Check out this project and the instructions in the readme for something similar for nodejs
https://github.com/joakin/cljs-node-repl/blob/master/README.md