How will self-hosted WordPress work with Google Page Speed Service?

Question

Google announced Page Speed Service, jumping on bandwagon of all-in-one site optimization and CDN.

• What are the potential issues, when configuring self-hosted WordPress for it?

• How will setting up reference domain work with WP? Considering that is required for Google to pull content, but public site URL will be different.

• Will it be possible to set it up with multisite?

• Should static caching plugins be left enabled or disabled for better compatibility?

• How will it work with wp-admin and Ajax? Should those be blacklisted in service settings?

PS this is intended to be large reference question, so feel free to edit in your own questions on subject