What happens to uninterpreted predicates in Ackermann's reduction?

Question

I know the procedure to apply the Ackermann's reduction to a formula that doesn't involve uninterpreted predicates. But, how do we treat the uninterpreted boolean predicates? Nearly all the examples I have seen, usually just assume there are no uninterpreted predicates, and give examples of simpler reductions, but if we have something like this:

$$p(z, F(x_1)) \wedge F(F(x_1)) = G(x_2,G(x_1,x_3,x_4),F(x_2)) \rightarrow p(x_1,y)$$

How will I get rid of the uninterpreted predicate, so that I can apply the usual reduction?