Were there major changes in testing practices in ASP .NET between 3.5 and 4.5?

Question

Obviously, testing methods are language-independent. An integration test stays an integration test no matter what the technology.

But platforms implement some kinds of testing support. And the details vary between implementations, so a programmer has to learn how to use the tools of their framework. And platforms evolve, so best practices in one version may become obsolete or at least inefficient in the next version. See for example this StackOverflow question about unit tests for which at least the first three answers seem to be valid: One describing the correct solution for the current version, one describing the solution which used to be best before the .NET framework included an ExpectedException attribute, and one describing a generic solution which is tool-independent.

My question is: were there any major testing-related changes between the .NET framework versions 3.5 and 4.5? Something as disruptive to testing as introducing generics was to programming in general, or introducing the Membership framework was to authentication? Or were there only small enhancing changes?

I am asking this because I wonder whether learning materials written for 3.5 are still reasonably valid today.