SharePoint and Office Integration not working in IE

Question

We have SharePoint 2013 Enterprise, Office Pro Plus, Windows 7, and IE 11.

Connect to Outlook, Export to Excel, Customize Form (InfoPath), and basically all other Office Integration points seem to be failing in IE. Connect to Outlook works correctly in Chrome.

• Minimal Download Strategy is turned off
• SharePoint is in the Intranet Zone
• IE Protected Mode is off

I suspect there is something wrong with our IE Add-ons, or that the upgrade to Office Pro Plus did not work correctly, potentially the Office Uninstaller does not cleanly uninstall Office. Has anyone ran into this issue before?

IE Connect To Outlook

Chrome Connect To Outlook This works when clicked.

Export To Excel

Customize Form - InfoPath

Installed IE Add-ons

Answer 1

The following change fixed this issue for me however removing virtual components functionality could have negative implications to other applications:

HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\AppV\Client\Virtualization

ProcessesUsingVirtualComponents (Multi-String Value)

Deleted:

%ProgramFiles%\Internet Explorer\iexplore.exe

%ProgramFiles(x86)%\Internet Explorer\iexplore.exe