no...
You can:
create an in-memory DB instance (specify in connection string
Data Source=:memory:
) and load the contents from the DB file into that instance... when you change contents of the in-memory instance your DB file won't get updated... you could later on save the in-memory instance content into a DB file... one way to do thisuse a RAM disk and copy the db file into that RAM disk...
modify the source code of the library to support MMF