This can be done using BaseDocTemplate
and Frame
as you can read here. I modified that receipe to only use a two frame layout:
from reportlab.platypus import BaseDocTemplate, Frame, Paragraph, PageBreak, PageTemplate
from reportlab.lib.styles import getSampleStyleSheet
import random
words = "lorem ipsum dolor sit amet consetetur sadipscing elitr sed diam nonumy eirmod tempor invidunt ut labore et".split()
styles=getSampleStyleSheet()
Elements=[]
doc = BaseDocTemplate('basedoc.pdf',showBoundary=1)
#Two Columns
frame1 = Frame(doc.leftMargin, doc.bottomMargin, doc.width/2-6, doc.height, id='col1')
frame2 = Frame(doc.leftMargin+doc.width/2+6, doc.bottomMargin, doc.width/2-6, doc.height, id='col2')
Elements.append(Paragraph(" ".join([random.choice(words) for i in range(1000)]),styles['Normal']))
doc.addPageTemplates([PageTemplate(id='TwoCol',frames=[frame1,frame2]), ])
#start the construction of the pdf
doc.build(Elements)