I don't think such a curated list exists. Smaller ones do exist, for example the 100 top movies quotes on Wikipedia. However, these are not updated.
One possibility is to filter out the aspects of your input that appear on another social media site that tracks trends, such as Delicious. Unless you are looking for trends, something that rises to the top of two trending sites likely ... is just a trend.
Delicious has a nice Python wrapper for its API.
In Pythonic pseudocode,
data = social-media.content
data = filter(lambda datum: datum not in delicious.content-list,data)