I am not entirely sure what you mean by loading it in runtime, but I assume you intend to also call the compiler at runtime then and supply it with that plugin.
In that case, yes this is possible. You can take a look at RunPlugin.scala from the alacs test suite for an example. The project's not really active anymore, but it provided compiler plugins for additional checks, which are also tested via a test suite involving the above class for runtime compilation with selected plugins.