You don't need Server.MapPath
since you have a full path; but:
- I imagine that s: will only be a mapped drive from a user login, not from IIS
- you'll need to reference the full network path, e.g. \servername\share...
- the account that IIS runs under will need network access to that share on the other server
You would be far better served (no pun intended!) importing that .mdb into SQL Server and connecting to it that way.