As others have answered, you cannot run an IPA file on the simulator, because the simulator runs native code on your Mac's x86 CPU while an IPA file only contains code for the device's ARM CPU.
What you can do is run an AirPlay server on your Mac. Install the IPA on your iOS device and turn on mirroring from the device to your Mac. Then record your Mac's screen.
There are several AirPlay server apps for the Mac. One that I've played with is Reflector. It supports recording the device's AirPlay stream directly to a video file, which makes the process even easier.