There are fitting functions built into SciPy but I do not know of any which account for uncertainties in data as MPFITFUN does. I have found Sherpa to be an excellent modeling and fitting package for Python which accounts for uncertainties and replaces MPFITFUN: http://cxc.harvard.edu/contrib/sherpa/
Since Sherpa is produced by astronomers it has a lot of built in astrophysical models, but you can build your own function to fit with Sherpa's Levenberg-Marquardt, Nelder-Mead or Monte Carlo algorithms. I used the template from the pysherpa blog: http://pysherpa.blogspot.com/2010/06/user-defined-sherpa-model-types-using.html