Here is an example of an Orika ClassMapBuilder supporting custom annotations, I think you can adapt it to meet your needs.
Gist : AnnotationClassMapBuilder
For Node (or DBObject of MongoDB) you can use a custom property resolver, take a look at: http://orika-mapper.github.com/orika-docs/advanced-mappings.html (ElementPropertyResolver)
Edit
Orika build mappers by class-map which are actually, just a collection of property-pair, property can be any thing which has name, type and setter or/and getter.
You can automatically create for each attribute in your beans an equivalent in Neo4J side, and let Orika build the mapper.
For example you can create a Person(name)->PrintStream mapper, in which you create for each person's property (name) an equivalent that print data (System.out)
Example
final Builder name = new Property.Builder()
.name("name")
.type(String.class.getName())
.setter("append(\"My name : \").append(%s).append('\\n')");
factory.classMap(Person.class, PrintStream.class).fieldMap("name", name, false).add().register();
factory.getMapperFacade().map(person, System.out); // This print to default output stream, My name : xxxx