You can use a normal command or Expression Blend's CallMethodAction, InvokeCommandAction or ChangePropertyAction.
Here are four ways to do what you want:
<Button Content="Button" Height="23" Width="100" Command="{Binding RaiseItCmd}">
<i:Interaction.Triggers>
<i:EventTrigger EventName="Click">
<i:InvokeCommandAction Command="{Binding RaiseItCmd}"/>
<ei:CallMethodAction MethodName="RaiseIt" TargetObject="{Binding}"/>
<ei:ChangePropertyAction Value=""
PropertyName="MyContentProperty" TargetObject="{Binding}"/>
</i:EventTrigger>
</i:Interaction.Triggers>
</Button>
Here I'm using MVVM Light's ViewModelBase:
using System.Windows.Input;
using GalaSoft.MvvmLight;
using Microsoft.Expression.Interactivity.Core;
public class ViewModel : ViewModelBase
{
public ViewModel()
{
RaiseItCmd = new ActionCommand(this.RaiseIt);
}
public string MyContentProperty
{
get
{
return "property";
}
set
{
this.RaiseIt();
}
}
public void RaiseIt()
{
RaisePropertyChanged("MyContentProperty");
}
public ICommand RaiseItCmd { get; private set; }
}